ATGAM is the purified, concentrated and sterile gamma globulin, primarily During processing, the drug is adsorbed with human erythrocyte stroma and with . Globulin [Equine] Sterile Solution. Brand Name Equivalent: Atgam® Product Insert “Preservative Information” indicates that this product does not contain. Brand names: Atgam, Lymphoglobuline, Thymogam up ↑ Antithymocyte globulin, horse ATG (Atgam) package insert (locally hosted backup).
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There was no difference in the patient survival rate between the two treatment groups. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in packkage practice.
Start dosing at the low end of the dosage range. ATGAM has been administered safely atgqm a small number of pediatric renal allograft recipients and pediatric aplastic anemia patients at dosage levels comparable to those in adults. Flank pain, Muscle rigidity, Myalgia, Pain in extremity Renal and urinary disorders: The dose for an elderly patient should be selected with caution, starting at the low end of the dosage range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy in this age group.
Use of antithymocyte globulin for reversal of acute allograft rejection. Experience with children has been limited. ATGAM is indicated for the management of allograft rejection in renal transplant patients; when administered with conventional therapy at the time of rejection ATGAM increases the frequency of resolution of the acute rejection episode [see Clinical Studies Hyperhidrosis Musculoskeletal and connective tissue disorders: Use only if the potential benefit justifies the risk.
Five patients had asymptomatic sinus bradycardia; six patients required antihypertensive therapy. Monitor packagr for concurrent infection. Antithymocyte globulins can cause anaphylaxis when injected intravenously. While the etiology of this toxicity is uncertain, it may be attributed to hemolytic anemia due to cross-reactivity of ATGAM to a monkey red blood antigen.
ATGAM is used with concomitant immunosuppressants. Serum sickness occurred in all patients within 6 to 18 days of ATGAM initiation and was well-controlled with standard therapy.
In the presence of a locally positive skin test to ATGAM, serious consideration to alternative forms of therapy should be given. Published data indicate that the primary mechanism is the depletion of circulating lymphocytes, with greatest effect on T lymphocytes.
There are no adequate and well-controlled studies in pregnant women. Healthcare providers should refer to labels. The range for half-life was 1. Patients were enrolled at the time of first rejection episode and randomized among three treatment groups: In addition, immunosuppression may be mediated by the binding of antibodies to lymphocytes packahe results in partial activation and induction of T lymphocyte anergy.
Indication Dosage Renal transplant rejection. It may develop a slight granular or flaky deposit during storage [see Dosage and Administration 2. The most clinically significant adverse reactions are anaphylaxis, infection, thrombocytopenia, leukopenia, arthralgia, edema, bradycardia, and abnormal renal and liver function tests.
A randomized double-blind, placebo prospective, controlled study was conducted to compare the safety and efficacy of ATGAM and androgen oxymetholone; OXY immunosuppressive therapy with the combination of ATGAM, androgen OXY and an infusion of HLA mismatched bone marrow in patients with severe aplastic anemia who were not candidates for bone marrow transplantation.
However, because ATGAM is a gamma globulin attam, it can be transparent to slightly opalescent, colorless to faintly pink or brown, and may develop a slight granular or flaky deposit during storage. The objective of this study was atgqm determine the efficacy of ATGAM as a single agent, in restoring hematopoiesis atagm patients with moderate to severe aplastic anemia.
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A maximum therapeutic dose has not been established therefore the definition of overdose for ATGAM has not been clearly defined. Because reactions are packabe voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Adverse reactions in both groups were comparable and included rash, chills, gastrointestinal disturbances, and joint pain during ATGAM infusion, as well as symptoms of serum sickness in all patients. Transplantation ; 31 2: Due to the small sample size, the difference between the ATGAM group and the control group in functional graft survival rate did not achieve statistical significance. Musculoskeletal and connective tissue disorders: In this patient, the administration of ATGAM was not associated with any signs of acute intoxication or late sequelae.
Inform patients that ATGAM may cause serious allergic reactions, infection or abnormal liver or renal function.
ATGAM is composed of antibodies that bind a wide variety of proteins on the surface of lymphocytes. General disorders and administration site conditions: Improved cadaveric renal transplant outcome in children.
Because ATGAM is made from equine and human blood components, it may carry a risk of transmitting infectious agents, e. Three patients experienced transient hypotension.